Thanks for your response and thoughtful questions! Yes, some work has been done on improving vaccine response through medication that reduces inflammation. Here is an example: https://stm.sciencemag.org/content/10/449/eaaq1564?ijkey=e8ef1ab60d51e2315e94fe26cf49b9f9353b59f8&keytype2=tf_ipsecsha

However, improving vaccine response is not as simple as just reducing any sort of inflammation because the immune system also needs to be stimulated enough to recognize a vaccine a foreign. It’s a very complex process that researchers are investigating extensively particularly in light of the pandemic.

Aspirin does have anti-inflammatory properties, and it has been shown to reduce risk of heart attacks in individuals with coronary artery disease (CAD) and in those at high risk for CAD. I’m not aware of any specific studies on aspirin and inflammaging itself. Inflammaging is an important concept but still fairly nebulous and difficult to measure whereas the effects of inflammaging are more easily defined. Other issues to consider with aspirin include its bleeding risk, weakening effect on the lining of the stomach, and potential adverse effect on the kidneys. Definitely something to talk about with your doctor if you are considering taking aspirin on a regular basis.